Over the years, NCIS has seen several of its main characters leave the series, each for different reasons. Mark Harmon, who portrayed the iconic Leroy Jethro Gibbs, stepped down in 2021 after nearly two decades on the show. His decision was reportedly driven by a desire to scale back his workload and spend more time with his family, though he remains involved as an executive producer. Michael Weatherly, who played Tony DiNozzo, left in 2016 to pursue new opportunities, including his lead role on Bull. Weatherly has since expressed a desire to return, but his exit at the time was driven by a need for creative exploration.

Pauley Perrette, known for her role as Abby Sciuto, left NCIS in 2018 after 15 seasons, citing personal reasons and safety concerns behind the scenes. Her departure came with some tension, but Perrette has since retired from acting and focused on her advocacy work. Cote de Pablo, who portrayed Ziva David, left the series in 2013 to explore new opportunities and creative projects. Though fans were heartbroken by her exit, de Pablo returned for guest appearances, providing some closure to her character’s storyline. Each actor’s departure was shaped by both personal and professional motivations, marking significant transitions for the series.